Researcher Details |

Andrew Kellett

Prof

Andrew Kellett is Professor of Inorganic and Medicinal Chemistry in the School of Chemical Sciences at Dublin City University, Ireland. His group are based at the Nano Research Facility (NRF) and the National Institute for Cellular Biotechnology (NICB) and focus on artificial gene editing, metallodrug discovery, and therapeutic nucleic acids. He is a back-to-back coordinator of the Horizon 2020 Marie Sk?odowska-Curie Innovative Training Network (ITN) ��_��-Ͷע|��Gene and NATURE-ETN. His lab is supported by Science Foundation Ireland (SFI), the Irish Research Council (IRC) and the SFI funded Synthesis and Solid-State Pharmaceutical Centre (SSPC) and C?RAM. He is a graduate of Maynooth University (B.Sc.) and Technological University Dublin (PhD) and was then appointed as A.F. Graves Postdoctoral Fellow at the Focas Research Institute until 2011 and thereafter joined the School of Chemical Sciences at Dublin City University. In 2022 he was named the SSPC's 'Investigator of the Year' and he also received a prestigious Irish Research Council (IRC) Laureate Consolidator Award.

Group website: http://www.andrewkellettgroup.com

Book Chapter

	Year	Publication
	2022	Anna Banasiak; Nicol�� Zuin Fantoni; Andrew Kellett; John Colleran (2022) 'Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors' In: Biomimetic Radical Chemistry and Applications 2021. Basel : MDPI. [Link] [DOI]
	2020	Molphy Z., McKee V., Kellett A. (2020) 'Biomimetic Radical Chemistry and Applications' In: Biomimetic Radical Chemistry and Applications. Basel, Switzerland : MDPI.
	2019	Kellett, A.; Molphy, Z.; McKee, V.; Slator, C. (2019) 'Recent Advances in Anticancer Copper Compounds' In: Rsc Metallobiology. [Link] [DOI]
	2019	Kellett, A; Molphy, Z; Mckee, V; Slator, C (2019) 'Recent Advances in Anticancer Copper Compounds' In: METAL-BASED ANTICANCER AGENTS. CAMBRIDGE : ROYAL SOC CHEMISTRY.
	2015	Molphy Z., Slator C., Chatgilialoglu C., Kellett A. (2015) 'DNA oxidation profiles of copper phenanthrene chemical nucleases' In: Monari A., Dumont E. and Chatgilialoglu C(Eds.). Radiation-induced and oxidative DNA damages. Lausanne : Frontiers Media. [DOI]

Peer Reviewed Journal

	Year	Publication
	2023	Bethany Searle; Markus M��ller; Thomas Carell; Andrew Kellett (2023) 'Third Generation Sequencing of Epigenetic DNA'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, . [Link] [DOI]
	2023	Se��n O��Halloran; Abhay Pandit; Andreas Heise; Andrew Kellett (2023) 'Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies'. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), 10 . [Link] [DOI]
	2022	de Souza, ?P; de Melo, ACC; Rodrigues, BL; Bortoluzzi, A; Poole, S; Molphy, Z; McKee, V; Kellett, A; Fazzi, RB; da Costa Ferreira, AM; Pereira-Maia, EC (2022) 'Antitumor copper(II) complexes with hydroxyanthraquinones and N,N-heterocyclic ligands'. Journal of Inorganic Biochemistry, 241 . [DOI]
	2022	McGorman, B; Fantoni, NZ; O'Carroll, S; Ziemele, A; El-Sagheer, AH; Brown, T; Kellett, A (2022) 'Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications'. Nucleic Acids Research, . [DOI]
	2022	Banasiak, A.; Fantoni, N.Z.; Kellett, A.; Colleran, J. (2022) 'Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors'. Molecules, 27 . [Link] [DOI]
	2022	Anna Clara Milesi Galdino; L��via Viganor; Matheus Mendon?a Pereira; Michael Devereux; Malachy McCann; Marta Helena Branquinha; Zara Molphy; Sin��ad O��Carroll; Conor Bain; Georgia Menounou; Andrew Kellett; Andr�� Luis Souza dos Santos (2022) 'Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa'. Journal of Biological Inorganic Chemistry, 27 :201-213. [DOI]
	2021	Fantoni NZ; Molphy Z; O'Carroll S; Menounou G; Mitrikas G; Krokidis MG; Chatgilialoglu C; Colleran J; Banasiak A; Clynes M; Roche S; Kelly S; McKee V; Kellett A; (2021) 'Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition'. Chemistry - A European Journal, 27 (3). [DOI]
	2021	Hennessy, J; McGorman, B; Molphy, Z; Farrell, NP; Singleton, D; Brown, T; Kellett, A (2021) 'A ��_��-Ͷע\|�� Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II) Modified Triplex Forming Oligonucleotides'. Angewandte Chemie (International ed. in English), 61 . [DOI]
	2021	McStay, N; Slator, C; Singh, V; Gibney, A; Westerlund, F; Kellett, A (2021) '��_��-Ͷע\|�� and Cut: a click chemistry approach to developing oxidative DNA damaging agents'. Nucleic Acids Research, . [DOI]
	2021	Fantoni, N.Z.; Molphy, Z.; O'Carroll, S.; Menounou, G.; Mitrikas, G.; Krokidis, M.G.; Chatgilialoglu, C.; Colleran, J.; Banasiak, A.; Clynes, M.; Roche, S.; Kelly, S.; McKee, V.; Kellett, A. (2021) 'Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition'. Chemistry (Weinheim an der Bergstrasse, Germany), 27 . [Link] [DOI]
	2020	Lauria, T; Slator, C; McKee, V; Muller, M; Stazzoni, S; Crisp, AL; Carell, T; Kellett, A (2020) 'A ��_��-Ͷע\|�� Chemistry Approach to Developing Molecularly Targeted DNA Scissors'. Chemistry - A European Journal, . [DOI]
	2020	Rochford, G.; Molphy, Z.; Kavanagh, K.; McCann, M.; Devereux, M.; Kellett, A.; Howe, O. (2020) 'Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis'. Metallomics, 12 . [Link] [DOI]
	2020	Rochford, Garret and Molphy, Zara and Kavanagh, Kevin and McCann, Malachy and Devereux, Michael and Kellett, Andrew and Howe, Orla (2020) 'Cu(ii) phenanthroline�Cphenazine complexes dysregulate mitochondrial function and stimulate apoptosis'. 12 :65-78. [Link] [DOI]
	2020	Suk, M; Haiss, A; Westphal, J; Jordan, A; Kellett, A; Kapitanov, IV; Karpichev, Y; Gathergood, N; Kummerer, K (2020) 'Design rules for environmental biodegradability of phenylalanine alkyl ester linked ionic liquids'. Green Chemistry, 22 :4498-4508. [DOI]
	2020	Panattoni A; El-Sagheer AH; Brown T; Kellett A; Hocek M; (2020) 'Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, (7):991-1000. [DOI]
	2020	Fantoni, NZ; McGorman, B; Molphy, Z; Singleton, D; Walsh, S; El-Sagheer, AH; McKee, V; Brown, T; Kellett, A (2020) 'Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, . [DOI]
	2020	Panattoni, A; El-Sagheer, AH; Brown, T; Kellett, A; Hocek, M (2020) 'Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, 21 :991-1000. [DOI]
	2020	Suk, Morten and Hai?, Annette and Westphal, Janin and Jordan, Andrew and Kellett, Andrew and Kapitanov, Illia V. and Karpichev, Yevgen and Gathergood, Nicholas and K��mmerer, Klaus (2020) 'Design rules for environmental biodegradability of phenylalanine alkyl ester linked ionic liquids'. . [Link] [DOI]
	2019	Zuin Fantoni N.; Molphy Z.; Slator C.; Menounou G.; Toniolo G.; Mitrikas G.; McKee V.; Chatgilialoglu C.; Kellett A. (2019) 'Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease'. Chemistry - A European Journal, . [DOI]
	2019	McStay N.; Reilly A.; Gathergood N.; Kellett A. (2019) 'Efficient DNA Condensation by a C3-Symmetric Codeine Scaffold'. ChemPlusChem, . [DOI]
	2019	Kapitanov, I.V.; Jordan, A.; Karpichev, Y.; Spulak, M.; Perez, L.; Kellett, A.; K��mmerer, K.; Gathergood, N. (2019) 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of l-phenylalanine-derived surface-active ionic liquids'. Green Chemistry, 21 . [Link] [DOI]
	2019	de Souza, IP; Machado, BD; de Carvalho, AB; Binatti, I; Krambrock, K; Molphy, Z; Kellett, A; Pereira-Maia, EC; Silva-Caldeira, PP (2019) 'Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands'. Journal of Molecular Structure, 1178 :18-28. [DOI]
	2019	Molphy, Zara and McKee, Vickie and Kellett, Andrew (2019) 'Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove'. 24 (23). [Link] [DOI]
	2019	Krokidis, Marios G. and Molphy, Zara and Efthimiadou, Eleni K. and Kokoli, Marianna and Argyri, Smaragda-Maria and Dousi, Irini and Masi, Annalisa and Papadopoulos, Kyriakos and Kellett, Andrew and Chatgilialoglu, Chryssostomos (2019) 'Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N��-dialkyl-9,9��-biacridylidenes'. 9 (5). [Link] [DOI]
	2020	Barrett, S.; De Franco, M.; Kellett, A.; Dempsey, E.; Marzano, C.; Erxleben, A.; Gandin, V.; Montagner, D. (2020) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal of Biological Inorganic Chemistry, 25 . [Link] [DOI]
	2019	Kellett, A.; Molphy, Z.; Slator, C.; McKee, V.; Farrell, N.P. (2019) 'Molecular methods for assessment of non-covalent metallodrug-DNA interactions'. Chemical Society Reviews, 48 . [Link] [DOI]
	2019	I.V. Kapitanov; A. Jordan; Y. Karpichev; M. Spulak; L. Perez; A. Kellett, K. K��mmerer; N. Gathergood (2019) 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids'. Green Chemistry, 21 :1777-1794. [DOI]
	2019	Molphy Z.; McKee V.; Kellett A. (2019) 'Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove'. Molecules, 24 (23). [DOI]
	2019	Krokidis, M.G.; Molphy, Z.; Efthimiadou, E.K.; Kokoli, M.; Argyri, S.M.; Dousi, I.; Masi, A.; Papadopoulos, K.; Kellett, A.; Chatgilialoglu, C. (2019) 'Assessment of dna topoisomerase i unwinding activity, radical scavenging capacity, and inhibition of breast cancer cell viability of n-alkylacridones and n,n��-dialkyl-9,9��-biacridylidenes'. Biomolecules, 9 . [Link] [DOI]
	2019	Ude, Z.; Kavanagh, K.; Twamley, B.; Pour, M.; Gathergood, N.; Kellett, A.; Marmion, C.J. (2019) 'A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties'. Dalton Transactions, 48 . [Link] [DOI]
	2018	Toniolo G.; Louka M.; Menounou G.; Fantoni N.; Mitrikas G.; Efthimiadou E.; Masi A.; Bortolotti M.; Polito L.; Bolognesi A.; Kellett A.; Ferreri C.; Chatgilialoglu C. (2018) '[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity'. Acs Omega, 3 (11):15952-15965. [DOI]
	2018	Slator, C; Molphy, Z; Mckee, V; Long, C; Brown, T; Kellett, A (2018) 'Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination'. Nucleic Acids Research, 46 :2733-2750. [DOI]
	2018	McGivern T.; Slator C.; Kellett A.; Marmion C. (2018) 'Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress'. Molecular Pharmaceutics, . [DOI]
	2018	Molphy, Z.; Montagner, D.; Bhat, S.S.; Slator, C.; Long, C.; Erxleben, A.; Kellett, A. (2018) 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'. Nucleic Acids Research, 46 . [Link] [DOI]
	2018	Rochford G.; Molphy Z.; Browne N.; Surlis C.; Devereux M.; McCann M.; Kellett A.; Howe O.; Kavanagh K. (2018) 'In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes'. Journal of Inorganic Biochemistry, 186 :135-146. [DOI]
	2017	McStay, N; Molphy, Z; Coughlan, A; Cafolla, A; McKee, V; Gathergood, N; Kellett, A (2017) 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, 45 :527-540. [DOI]
	2017	McStay, N; Molphy, Z; Gathergood, N; Kellett, A (2017) 'OPIOID ARCHITECTURES AS NEW DNA BINDING MOLECULES'. Symmetry-Culture And Science, 28 :195-198.
	2017	Slator, C.; Molphy, Z.; McKee, V.; Kellett, A. (2017) 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'. Redox Biology, 12 . [Link] [DOI]
	2017	McStay, N.; Molphy, Z.; Gathergood, N.; Kellett. A. (2017) 'Opioid architectures as new DNA binding molecules'. Symmetry, 28 (24):195-198. [Link] http://journal-scs.symmetry.hu/content-pages/volume-28-number-2-pages-161-240-2017/
	2016	Terzidis, M.A.; Prisecaru, A.; Molphy, Z.; Barron, N.; Randazzo, A.; Dumont, E.; Krokidis, M.G.; Kellett, A.; Chatgilialoglu, C. (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radical Research, 50 . [Link] [DOI]
	2016	McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
	2016	Kelly, P.S.; McSweeney, S.; Coleman, O.; Carillo, S.; Henry, M.; Chandran, D.; Kellett, A.; Bones, J.; Clynes, M.; Meleady, P.; Barron, N. (2016) 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'. Biotechnology Progress, 32 . [Link] [DOI]
	2016	Thornton L.; Dixit V.; Assad L.; Ribeiro T.; Queiroz D.; Kellett A.; Casey A.; Colleran J.; Pereira M.; Rochford G.; McCann M.; O'Shea D.; Dempsey R.; McClean S.; Kia A.; Walsh M.; Creaven B.; Howe O.; Devereux M. (2016) 'Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity'. Journal of Inorganic Biochemistry, 159 :120-132. [DOI]
	2016	Viganor, L.; Galdino, A.C.M.; Nunes, A.P.F.; Santos, K.R.N.; Branquinha, M.H.; Devereux, M.; Kellett, A.; McCann, M.; Santos, A.L.S. (2016) 'Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells'. Journal of Antimicrobial Chemotherapy, 71 . [Link] [DOI]
	2016	Kelly, PS; McSweeney, S; Coleman, O; Carillo, S; Henry, M; Chandran, D; Kellett, A; Bones, J; Clynes, M; Meleady, P; Barron, N (2016) 'Process-Relevant Concentrations of the Leachable bDtBPP Impact Negatively on CHO Cell Production Characteristics'. Biotechnology Progress, 32 :1547-1558. [DOI]
	2016	Slator C., Barron N., Howe O., Kellett A. (2016) '[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. ACS chemical biology, 11 :159-171. [DOI]
	2015	Molphy Z., Slator C., Chatgilialoglu C., and Kellett A. (2015) 'DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases'. FRONTIERS IN CHEMISTRY, 3 :1-9. [Link] [DOI]
	2015	Fantoni N.; Lauria T.; Kellett A. (2015) 'Genome Engineering with Synthetic Copper Nucleases'. Synlett, 26 (19):2623-2626. [DOI]
	2015	Larragy R.; Fitzgerald J.; Prisecaru A.; McKee V.; Leonard P.; Kellett A. (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 (65):12908-12911. [DOI]
	2015	Larragy, R; Fitzgerald, J; Prisecaru, A; Mckee, V; Leonard, P; Kellett, A (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 :12908-12911. [DOI]
	2014	Molphy, Z.; Prisecaru, A.; Slator, C.; Barron, N.; McCann, M.; Colleran, J.; Chandran, D.; Gathergood, N.; Kellett, A. (2014) 'Copper phenanthrene oxidative chemical nucleases'. Inorganic Chemistry, 53 . [Link] [DOI]
	2014	Prisecaru A.; Molphy Z.; Kipping R.; Peterson E.; Qu Y.; Kellett A.; Farrell N. (2014) 'The phosphate clamp: Sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'. Nucleic Acids Research, 42 (22):13474-13487. [DOI]
	2013	Prisecaru, A.; McKee, V.; Howe, O.; Rochford, G.; McCann, M.; Colleran, J.; Pour, M.; Barron, N.; Gathergood, N.; Kellett, A. (2013) 'Regulating bioactivity of Cu²⁺ Bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates'. Journal of Medicinal Chemistry, 56 . [Link] [DOI]
	2013	McCann M., McGinley J., Ni K., O'Connor M., Kavanagh K., McKee V., Colleran J., Devereux M., Gathergood N., Barron N., Prisecaru A. and Kellett A. (2013) 'A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction'. CHEMICAL COMMUNICATIONS (PRINT), 49 :2341-2343. [DOI]
	2013	Mc Cann, M.; Mc Ginley, J.; Ni, K.; O��connor, M.; Kavanagh, K.; Mc Kee, V.; Colleran, J.; Devereux, M.; Gathergood, N.; Barron, N.; Prisecaru, A.; Kellett, A. (2013) 'A new phenanthroline�Coxazine ligand: Synthesis, coordination chemistry and atypical DNA binding interaction'. Chemical Communications, 49 . [Link] [DOI]
	2013	McCann M.; Curran R.; Ben-Shoshan M.; McKee V.; Devereux M.; Kavanagh K.; Kellett A. (2013) 'Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles'. Polyhedron, 56 :180-188. [DOI]
	2013	Kellett A.; Prisecaru A.; Slator C.; Molphy Z.; McCann M. (2013) 'Metal-based antimicrobial protease inhibitors'. Current Medicinal Chemistry, 20 (25):3134-3151. [DOI]
	2012	McCann M.; Santos A.; Da Silva B.; Romanos M.; Pyrrho A.; Devereux M.; Kavanagh K.; Fichtner I.; Kellett A. (2012) 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes'. Toxicology Research, 1 (1):47-54. [DOI]
	2012	McCann M.; Curran R.; Ben-Shoshan M.; McKee V.; Tahir A.; Devereux M.; Kavanagh K.; Creaven B.; Kellett A. (2012) 'Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: Synthesis, structure and antimicrobial activity'. Dalton Transactions, 41 (21):6516-6527. [DOI]
	2012	O'Connor, M.; Kellett, A.; McCann, M.; Rosair, G.; McNamara, M.; Howe, O.; Creaven, B.S.; McClean, S.; Foltyn-Arfa Kia, A.; O'Shea, D.; Devereux, M. (2012) 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'. Journal of Medicinal Chemistry, 55 . [Link] [DOI]
	2012	Kellett A.; McCann M.; Howe O.; O'Connor M.; Devereux M. (2012) 'DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- Phenanthroline terephthalate'. International Journal of Clinical Pharmacology and Therapeutics, 50 (1):79-81. [DOI]
	2012	Prisecaru, A.; Devereux, M.; Barron, N.; McCann, M.; Colleran, J.; Casey, A.; McKee, V.; Kellett, A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(��-terephthalate)(1,10-phen)4]²⁺n'. Chemical Communications, 48 . [Link] [DOI]
	2012	McCann, M.; Kellett, A.; Kavanagh, K.; Devereux, M.; Santos, A.L.S. (2012) 'Deciphering the antimicrobial activity of phenanthroline chelators'. Current Medicinal Chemistry, 19 . [Link]
	2012	Kellett, A.; Howe, O.; O'Connor, M.; McCann, M.; Creaven, B.S.; McClean, S.; Foltyn-Arfa Kia, A.; Casey, A.; Devereux, M. (2012) 'Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2��-dipyridyl'. Free Radical Biology and Medicine, 53 . [Link] [DOI]
	2012	Santos, A.L.S.; Sodr��, C.L.; Valle, R.S.; Silva, B.A.; Abi-Chacra, E.A.; Silva, L.V.; Souza-Gon?alves, A.L.; Sangenito, L.S.; Gon?alves, D.S.; Souza, L.O.P.; Palmeira, V.F.; D'Avila-Levy, C.M.; Kneipp, L.F.; Kellett, A.; McCann, M.; Branquinha, M.H. (2012) 'Antimicrobial action of chelating agents: Repercussions on the microorganism development, virulence and pathogenesis'. Current Medicinal Chemistry, 19 . [Link]
	2011	Kellett A., OConnor M., McCann M., Howe O., Casey A., McCarron P., McNamara M., Kennedy S., May D. D., Skell P. S., OShea D., Devereux M. (2011) 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development'. MEDICAL CHEMISTRY COMMUNICATIONS, 2 :569-676. [DOI]
	2011	Kellett A., OConnor M., McCann M., McNamara M., Lynch P., Rosair G., McKee V., Creaven B., Walsh M., McClean S., Foltyn A., OShea D., Howe O., Devereux M. (2011) 'Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties'. 40 :1024-1027.
	2010	Kellett, A., Rosair G., Devereux M., McNamara M., McCann M. (2010) 'Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate)'. ACTA CRYSTALLOGRAPHICA SECTION C, 66 :M358-M362.
	2010	Creaven B. S., Czegl��di E., Devereux M., Enyedy ?. A., Foltyn-Arfa Kia A., Karcz D., Kellett A., McClean S., Nagy N. V., Noble A., Rockenbauer A.,Szab��-Pl��nka T., Walsh M. (2010) 'Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands'. 39 :10854-10865.
	2009	Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M. (2009) 'Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity'. Journal of Inorganic Biochemistry, 103 :1196-1203.
	2007	Devereux M., O'Shea D., Kellett A., McCann M., Walsh M., Egan D., Deegan C., Kgdziora K., Rosair G., Mulller-Bunz H. (2007) 'Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands'. Journal of Inorganic Biochemistry, 101 :881-892.
	2007	Devereux M., O'Shea D., O'Connor M., Grehan H., Connor G., McCann M., Rosair G., Lyng F., Kellett A., Walsh M., Egan D., Thati B. (2007) 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)(2)(bipy)(H2O)], [Cu(SalH)(2)(BZDH)(2)] and [Cu(CH3COO)(2)(5,6-DMBZDH)(2)] (SalH(2) =salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)'. Polyhedron, 26 :4073-4084.
	2006	Devereux M., McCann M., O'Shea D., O'Connor M., Kiely E., McKee V., Naughton D., Fisher A., Kellett A., Walsh M., Egan D., Deegan C. (2006) 'Synthesis, superoxide dismutase mimetic and anticancer activities of metal complexes of 2,2-dimethylpentanedioic acid(2dmepdaH(2)) and 3,3-dimethylpentanedioic acid(3dmepdaH(2)): X-ray crystal structures of [Cu(3dmepda)(bipy)](2)center dot 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2)center dot 4EtOH (bipy=2,2 ' bipyridine)'. Bioinorganic Chemistry and Applications, 80283 .
	2021	Galdino, ACM; Viganor, L; Pereira, MM; Devereux, M; McCann, M; Branquinha, MH; Molphy, Z; O'Carroll, S; Bain, C; Menounou, G; Kellett, A; Dos Santos, ALS (2021) 'Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa'. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, . [DOI]
	2017	McStay, N; Molphy, Z; Coughlan, A; Cafolla, A; McKee, V; Gathergood, N; Kellett, A (2017) 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, 45 :527-540. [DOI]
	2017	Slator, C; Molphy, Z; Mckee, V; Kellett, A (2017) 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'. Redox Biology, 12 :150-161. [DOI]
	2016	Slator, C.; Barron, N.; Howe, O.; Kellett, A. (2016) 'Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. ACS chemical biology, 11 . [Link] [DOI]
	2016	McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
	2016	McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
	2016	Terzidis, MA; Prisecaru, A; Molphy, Z; Barron, N; Randazzo, A; Dumont, E; Krokidis, MG; Kellett, A; Chatgilialoglu, C (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radical Research, 50 :91-101. [DOI]
	2016	McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
	2016	McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
	2015	Larragy, R; Fitzgerald, J; Prisecaru, A; Mckee, V; Leonard, P; Kellett, A (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 :12908-12911. [DOI]
	2015	Larragy R., Fitzgerald J., Prisecaru A., McKee V., Leonard P. and Kellett A. (2015) 'Protein engineering with artificial chemical nucleases'. CHEMICAL COMMUNICATIONS (PRINT), 51 :12908-12911. [DOI]
	2015	Molphy, Z.; Slator, C.; Chatgilialoglu, C.; Kellett, A. (2015) 'DNA oxidation profiles of copper phenanthrene chemical nucleases'. FRONTIERS IN CHEMISTRY, 3 . [Link] [DOI]
	2015	Fantoni N., Lauria T., Kellett A. (2015) 'Genome Engineering with Synthetic Copper Nucleases'. in press . [DOI]
	2014	Molphy Z., Prisecaru A., Slator C., Barron, N., McCann M., Colleran J., Chandran D., Gathergood N. and Kellett A. (2014) 'Copper Phenanthrene Oxidative Chemical Nucleases'. Inorganic Chemistry, 53 :5392-5404.
	2014	Prisecaru A., Molphy Z., Kipping R.G., Peterson E.J., Qu Y., Kellett A., and Farrell N.P. (2014) 'The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'. 42 :13474-87.
	2013	Kellett, A; Prisecaru, A; Slator, C; Molphy, Z; McCann, M (2013) 'Metal-Based Antimicrobial Protease Inhibitors'. Current Medicinal Chemistry, 20 :3134-3151.
	2013	Kellett A., Prisecaru A., Slator C., Molphy Z., McCann M. (2013) 'Metal-Based Antimicrobial Protease Inhibitors'. Current Medicinal Chemistry, 20 :3134-3151.
	2013	Prisecaru A., Mckee V., Howe O., Rochford G., McCann M, Colleran J., Barron N., Pour M., Gathergood N. and Kellett A. (2013) 'Regulating Bioactivity of Cu2+ Bis-1,10-Phenanthroline Artificial Metallonucleases with Sterically Functionalised Pendant Carboxylates'. Journal of Medicinal Chemistry, 56 :8599-8615.
	2013	McCann M., Curran R., Ben-Shoshana M., McKee V., Devereux M., Kavanagh K., Kellett A. (2013) 'Synthesis, Structure and Biological Activity of Silver(I) Complexes of Substituted Imidazoles'. Polyhedron, 56 :180-188.
	2012	Prisecaru A., Devereux M., Barron N., McCann M., Colleran J., Casey A., McKee V. and Kellett A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(terephthalate)(1,10-phen)4]2+'. CHEMICAL COMMUNICATIONS (PRINT), 48 :6906-6908. [DOI]
	2012	McCann M., Santos A., da Silva B., Romanos M., Pyrrho A., Devereux M., Kavanagh K., Fichtner I. and Kellett A. (2012) 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes'. Toxicology Research, 1 :47-54.
	2012	O'Connor M., Kellett A., McCann M., Rosair G., McNamara M., Howe O., Creaven B., McClean S., Foltyn-Arfa Kia A., O'Shea D. and Devereux M. (2012) 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities exhibit low toxicity and display promising chemotherapeutic potential with fast acting in-vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'. Journal of Medicinal Chemistry, 55 :1957-1968.
	2012	Andr�� L.S. Santos, C��tia L. Sodr��, Roberta S. Valle, Bianca A. Silva, ?rika A. Abi-chacra, L��via V. Silva, Ana Luiza Souza-Gon?alves, Leandro S. Sangenito, Diego S. Gon?alves, Lucieri O.P. Souza, Vanila F. Palmeira, Claudia M. dAvila-Levy, Lucimar F. Kneipp, Andrew Kellett, Malachy McCann, Marta H. Branquinha (2012) 'Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis'. Current Medicinal Chemistry, 19 :2715-2737.
	2012	Andrew Kellett, Malachy McCann, Orla Howe, Mark OConnor and Michael Devereux (2012) 'DNA Cleavage Reactions of the Dinuclear Chemotherapeutic Agent Copper(II) Bis-1,10-Phenanthroline Terephthalate'. International Journal of Clinical Pharmacology and Therapeutics, 50 :79-81.
	2012	Kellett A., Howe O., OConnor M., McCann M., Creaven B., McClean S., Foltyn-Arfa Kia A., Casey A. and Devereux M. (2012) 'Radical Induced DNA Damage by Cytotoxic Square-Planar Copper(II) Complexes Incorporating o-Phthalate and 1,10-Phenanthroline or 2,2'-Dipyridyl'. Free Radical Biology and Medicine, 53 :564-576. [DOI]
	2012	Malachy McCann, Andrew Kellett, Kevin Kavanagh, Michael Devereux and Andr�� L. S. Santos (2012) 'Deciphering the Antimicrobial Activity of Phenanthroline Chelators'. Current Medicinal Chemistry, 19 :2703-2714.
	2012	McCann M., Curran R., Ben-Shoshan M., McKee V., Tahir A., Devereux M., Kavanagh K., Creaven B. and Kellett A. (2012) 'Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity'. 41 :6516-6527.
	2011	Kellett, A.; O'Connor, M.; McCann, M.; Howe, O.; Casey, A.; McCarron, P.; Kavanagh, K.; McNamara, M.; Kennedy, S.; May, D.D.; Skell, P.S.; O'Shea, D.; Devereux, M. (2011) 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu ²⁺ and Mn ²⁺ complexes with unprecedented nano and picomolar in vitro cytotoxicity: Promising leads for chemotherapeutic drug development'. MedChemComm, 2 . [Link] [DOI]

Conference Publication

	Year	Publication
	2018	Rochford, G; Molphy, Z; Browne, N; Surlis, C; Devereux, M; McCann, M; Kellett, A; Howe, O; Kavanagh, K (2018) JOURNAL OF INORGANIC BIOCHEMISTRY *In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes* [DOI]

Conference Contribution

	Year	Publication
	2016	Andrew Kellett (2016) TBSI Chemistry Seminar Series Metallodrugs as Inducers or Inhibitors of Chemical Nuclease Activity Trinity College Dublin, 25/02/2016-25/02/2016.
	2015	Kellett A. (2015) Wolfson CRL Chemical Biology Seminar Series Metallodrugs as inducers or inhibitors of chemical nuclease activity University of Oxford, 18/11/2015-18/11/2015.
	2015	Kellett A. (2015) 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity NUI Galway, 12/06/2015-15/06/2015.
	2015	Kellett A. (2015) Invited Lecture Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity NUI Galway, 05/03/2015-05/03/2015.
	2014	Kellett A. (2014) Brazilian Meeting on Inorganic Chemistry (BMIC) XVII, Invited Talk Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Arax��, Brazil, 10/08/2014-14/08/2014.
	2014	Kellett, A. (2014) Invited talk Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Universidade Federal do Rio de Janeiro, Brazil, 08/08/2014-08/08/2014.
	2014	Kellett, Andrew (2014) Invited Talk Copper(II) Oxidative Chemical Nucleases Department of Chemistry, Loughborough University, UK, 29/01/2014-29/01/2014.
	2014	Kellett, A. (2014) EUCHEM Conference on Organic Free Radicals Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Prague, 29/06/2014-04/07/2014.
	2014	Kellett A. (2014) COST Action CM1201: Biomimetic Radical Chemistry, WG4/WG1 Inter-Working Group Meeting NCI‐60 chemotherapeutic action of copper metallointercalators bear apoptotic hallmarks of hydroxyl radical induced death Puerto de la Cruz, Tenerife, Spain, 01/10/2014-03/10/2014.
	2014	Kellett, A. (2014) Invited talk Deciphering the Antimicrobial Action of Copper Phenazines through Proteomic Analysis Universidade Federal do Rio de Janeiro, Brazil, 07/08/2014-07/08/2014.
	2013	Andrew Kellett (2013) COST Action CM1201: Biomimetic Radical Chemistry, 1st Working Group Meeting (WG 2: Models of DNA Damage and Consequences) Copper Phenanthrene Oxidative Chemical Nucleases Athens, Greece, 17/10/2013-19/10/2013.
	2012	Andrew Kellett (2012) 2012 Symposium on Inorganic Chemistry in Ireland Copper Metallo-Nucleases in Cancer Chemotherapy National University of Ireland, Galway, 07/12/2012-.
	2011	Andrew Kellett (2011) Chemistry Lecture Seminar Series DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs? Dublin City University, 13/04/2011-.
	2011	Andrew Kellett, Michael Devereux, Malachy McCann, Mark OConnor, Pauraic McCarron, Alan Casey, and Orla Howe (2011) Central European Society for Anticancer Drug Research (CESAR) Annual Meeting DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs? Greifswald University Germany, 16/06/2011-18/06/2011.
	2010	Pauraic Mc Carron, Malachy McCann, Andrew Kellett, Michael Devereux (2010) 62nd Irish Universities Chemistry Research Colloquium Synthesis and Chemotherapeutic Potential of Manganese(II) 1,10-Phenanthroline/Phthalate Complexes Queens University Belfast, 01/07/2010-02/07/2010.
	2010	Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2010) 2nd Symposium on Inorganic Chemistry in Ireland Bis-Phenanthroline Copper(II) Complexes of Aromatic and Aliphatic Dicarboxylates are Potent In Vitro Antitumour Agents with ��Self-Activating�� Metallo-Nuclease & DNA Binding Properties Queens University Belfast, 17/09/2010-.
	2009	A. Kellett, M. Devereux, M. McNamara, M. McCann, M. OConnor, D. OShea, G. Rosair, V. McKee, M. Walsh and O. Howe (2009) Irish Institute of Metal Based Drugs (IIMBD) Symposium Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes Dublin Institute of Technology, 26/11/2009-.
	2009	Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2009) NUI Maynooth Chemistry Seminar Series Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes National University of Ireland Maynooth, 14/10/2009-.
	2007	Michael Devereux, Denis OShea, Mark OConnor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan and Bhumika Thati (2007) 59th Irish Universities Chemistry Research Colloquium Copper(II) Superoxide Dismutase Mimetics as Potential Anticancer Drugs Dublin City University, 13/06/2007-15/06/2007.
	2006	McCann M., Rowan R., Devereux D., Kellett A., Hilger R. (2006) Central European Society for Anticancer Drug Research (CESAR) Annual Meeting Silver Bullets in Anticancer Chemotherapy University Hospital, Essen, Germany, 12/07/2006-.
	2005	Andrew Kelett, Maureen Walsh, Michael Devereux, Helge Muller-Bunz, Vickie McKee and Georgina Rosair (2005) 3nd Annual Science Research Day ITTD Synthesis, characterisation and biological activity of copper(II) carboxylates incorporating selective N-donor ligands Institute of Technology Tallaght Dublin, 31/03/2005-.
	2004	Andrew Kellett, Michael Devereux, Maureen Walsh, Bernie Creaven, Malachy McCann, Denis O'Shea, Helge Muller-Bunz (2004) 8th annual science and computing research colloquium Novel Cu(II) Benzimidazole Complexes for the treatment of Candida Albicans Related Infections Waterford Institute of Technology, 26/05/2004-28/05/2004.
	2004	Andrew Kellett, Michael Devereux, Malachy McCann, Denis O'Shea, Maureen Walsh, Bernie Creaven, Helge Muller-Bunz (2004) 56th Irish Universities Chemistry Research Colloquium Copper(II) benzoate complexes incorporating benzimidazole ligands: Synthesis, structures and antifungal activity University of Limerick, 23/06/2004-25/06/2004.

Abstract

	Year	Publication
	2017	McGivern, T; Ude, Z; Kenny, R; Kellett, A; Marmion, CJ (2017) Rational design and development of metallodrug chemotypes for therapeutic exploitation. NEW YORK: ABST
	2017	Montagner, D; Erxleben, A; Miguel, PS; Kavanagh, K; Kellett, A (2017) Estrogens-functionalized metal complexes: selective anticancer and antibacterial activity. NEW YORK: ABST

Review Articles

	Year	Publication
	2019	Kellett, A; Molphy, Z; Slator, C; McKee, V; Farrell, NP (2019) Molecular methods for assessment of non-covalent metallodrug-DNA interactions. CAMBRIDGE: REV [DOI]

Other Publication

	Year	Publication
	2023	O'Halloran, S.; Pandit, A.; Heise, A.; Kellett, A. (2023) Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies. [Link] [DOI]
	2021	Fantoni, N.Z.; Brown, T.; Kellett, A. (2021) DNA-Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology. [Link] [DOI]

Research Interests

Design of inorganic materials as molecular scissors for DNA excision.
Nucleic acid binding interactions.
Free radical chemical biology at the DNA interface.
Metallo-cytotoxic drug design and mechanism.
Coordinator of the multimillion EU funded Marie Curie ITN research programme, ��_��-Ͷע|��Gene: ��_��-Ͷע|�� Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (H2020 - MSCA - ITN). www.clickgene.eu

Funding Opportunities

Irish Research Council

Link: www.research.ie

Postgraduate and Postdoctoral scholarship funding opportunities are regularly available through the IRC. Suitable candidates wishing to join this group are welcome to apply for an IRC scholarship, for more information please contact me by email.

Modules Coordinated

Term	Title	Subject
2022	Inorganic Chemistry Laboratory	CS254
2022	Computational and Inorganic Chemistry	CS308
2022	Inorganic & Physical Chemistry Lab	CS260
2022	Advanced Medicinal Chemistry	CS414
2022	Medicinal Chemistry	CS311
2022	Advanced Inorganic Chemistry	CS406