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    Philip Cummins

    Assoc. Prof

    Profile Photo
    Phil Cummins received his BSc in Biotechnology (1991) and PhD in Biochemistry (1995) from DCU, after which he undertook a Postdoctoral Research Fellowship with the Fishberg Centre for Neurobiology at the Mount Sinai School of Medicine in New York (1996-1999). Upon returning to Ireland, his further career has involved a Lectureship with IT-Tallaght (1999-2000), a Senior Scientist role with the Vascular Health Research Centre at DCU (2000-2007), and a permanent lectureship with the School of Biotechnology at DCU (2007-date). He is currently an Associate Professor of Vascular Biology and has mentored 20 PhD  students and postdoctoral fellows.

    Book Chapter

    Year Publication
    2019 Rochfort KD, Cummins PM (2019) 'In vitro cell models of the human blood-brain barrier: demonstrating the beneficial influence of shear stress on brain microvascular endothelial cell phenotype' In: Blood-Brain Barrier, NeuroMethods. New York, NY : Humana Press. [Link]
    2019 Laura Twomey, Robert G. Wallace, Philip M. Cummins, Bernard Degryse, Sinead Sheridan, Michael Harrison, Niall Moyna, Gerardene Meade-Murphy, Nastassia Navasiolava, Marc-Antoine Custaud and Ronan P. Murphy (2019) 'Platelets: From Formation to Function' In: Homeostasis: An Integrated Vision. London : InTechOpen. [Link]
    2017 Cummins PM, Rochfort KD, O'Connor BF. (2017) 'Ion-Exchange Chromatography: Basic Principles and Application' In: Methods in Molecular Biology Vol.1485. United States : Humana Press. [Link]
    2017 ?'Fágáin C, Cummins PM, O'Connor BF. (2017) 'Gel-Filtration Chromatography' In: Methods in Molecular Biology Vol.1485. United States : Humana Press. [Link]
    2017 O'Connor BF, Cummins PM. (2017) 'Hydrophobic Interaction Chromatography' In: Methods in Molecular Biology Vol.1485. United States : Humana Press. [Link]
    2011 Cummins PM, Dowling O, O'Connor BF. (2011) 'Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase' In: Walls D, Loughran ST(Eds.). Methods in Molecular Biology Vol.681. http://www.ncbi.nlm.nih.gov/pubmed/20978968 : Humana Press.
    2011 Cummins PM, O'Connor BF. (2011) 'Hydrophobic interaction chromatography' In: Walls D, Loughran ST(Eds.). Methods in Molecular Biology Vol.681. http://www.ncbi.nlm.nih.gov/pubmed/20978980 : Humana Press.
    2011 O'Fágáin C, Cummins PM, O'Connor BF. (2011) 'Gel-filtration chromatography' In: Walls D, Loughran ST(Eds.). Methods in Molecular Biology Vol.681. : Humana Press. http://www.ncbi.nlm.nih.gov/pubmed/20978958

    Peer Reviewed Journal

    Year Publication
    2023 Kostyunina DS, Rowan SC, Pakhomov NV, Dillon E, Rochfort KD, Cummins PM, O'Rourke MJ, McLoughlin P (2023) 'Shear stress markedly alters the proteomic response to hypoxia in human pulmonary endothelial cells'. American Journal of Respiratory Cell and Molecular Biology, . [Link] [DOI]
    2022 Forde H, Davenport C, Rochfort KD, Wallace RG, Durkan E, Agha A, Thompson CJ, Tormey WT, O’Gorman DJ, Cummins PM, Smith D (2022) 'Serum OPG/TRAIL ratio predicts the presence of cardiovascular disease in people with type 2 diabetes mellitus'. Diabetes Research and Clinical Practice, 89 . [Link] [DOI]
    2021 Wallace RG, Rochfort KD, Barabas P, Curtis TM, Uehara H, Ambati BK, Cummins PM. (2021) 'COMP-Ang1: Therapeutic potential of an engineered angiopoietin-1 variant'. Vascular Pharmacology, 141 (106919):1-8. [Link]
    2020 Harper E, Rochfort KD, Smith D, Cummins PM (2020) 'RANKL treatment of vascular endothelial cells leading to paracrine pro-calcific signaling involves ROS production'. Molecular and Cellular Biochemistry, 464 :111-117. [Link]
    2019 Rochfort KD, Carroll LS, Barabas P, Curtis TM, Ambati BK, Barron N, Cummins PM (2019) 'COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells'. Investigative Ophtalmology and Visual Science, 60 :3547-3555. [Link]
    2019 Carroll LS, Uehara H, Fang D, Choi S, Zhang X, Singh M, Sandhu Z, Cummins PM, Curtis TM, Stitt AW, Archer BJ, Ambati BK. (2019) 'Intravitreal AAV2.COMP-Ang1 attenuates deep capillary plexus expansion in the aged diabetic mouse retina'. Investigative Ophthalmology Visual Science, 60 :2494-2502. [Link]
    2018 Rowan SC, Rochfort KD, Piouceau L, Cummins PM, O'Rourke M, McLoughlin P (2018) 'Pulmonary endothelial permeability and tissue fluid balance depend on the viscosity of the perfusion solution'. American Journal of Physiology - Lung Cellular and Molecular Physiology, 315 :L476-L484. [Link]
    2018 Harper E, Rochfort KD, Forde H, Davenport C, Smith D, Cummins PM (2018) 'Activation of the non-canonical NF-kB/p52 pathway in vascular endothelial cells by RANKL elicits pro-calcific signalling in co-cultured smooth muscle cells'. Cellular Signalling, 47 :142-150. [Link]
    2018 Davenport C, Harper E, Rochfort KD, Forde H, Smith D, Cummins PM. (2018) 'RANKL inhibits the production of OPG from smooth muscle cells under basal conditions and following exposure to cyclic strain'. Journal of Vascular Research, 55 :111-123. [Link] [DOI]
    2018 Wallace RG, Twomey LC, Custaud MA, Turner J, Moyna N, Cummins PM, Murphy RP. (2018) 'The role of epigenetics in cardiovascular health and aging: a focus on physical activity and nutrition'. Mechanisms of Ageing and Development, 174 :76-85. [Link] [DOI]
    2017 Harper E, Rochfort KD, Forde H, Davenport C, Smith D, Cummins PM. (2017) 'TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models'. PLoS ONE, 12 . [Link]
    2017 Degryse B.;Britto M.;Shan C.;Wallace R.;Rochfort K.;Cummins P.;Meade G.;Murphy R. (2017) 'Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR'. Data In Brief, 15 :600-605. [DOI]
    2017 Degryse, B;Britto, M;Shan, CX;Wallace, RG;Rochfort, KD;Cummins, PM;Meade, G;Murphy, RP (2017) 'Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis'. International Journal of Biochemistry and Cell Biology, 88 :14-22. [DOI]
    2017 McLoughlin A, Rochford KD, McDonnell C, Kerrigan SW, Cummins PM (2017) 'Staphylococcus aureus-mediated blood-brain barrier injury: An in vitro human brain microvascular endothelial cell model'. Cellular Microbiology, 19 :1-11. [Link]
    2016 McDonnell CJ, Garciarena C, Watkin R, McHale TM, McLoughlin A, Claes J, Verhamme P, Cummins PM, Kerrigan SW (2016) 'Inhibition of αVβ3 reduces Staphylococcus aureus-mediated endothelial cell dysregulation: implications for the treatment of sepsis'. Journal of Thrombosis and Haemostasis, 14 :2536-2547. [Link]
    2016 Davenport C.;Harper E.;Forde H.;Rochfort K.;Murphy R.;Smith D.;Cummins P. (2016) 'RANKL promotes osteoblastic activity in vascular smooth muscle cells by upregulating endothelial BMP-2 release'. International Journal of Biochemistry and Cell Biology, 77 :171-180. [DOI]
    2016 Harper E, Forde H, Davenport C, Rochfort KD, Smith D, Cummins PM. (2016) 'Vascular calcification in type-2 diabetes and cardiovascular disease: integrative roles for OPG, RANKL and TRAIL'. Vascular Pharmacology, doi: 10.1016/j.vph.2016.02.003 . [Link]
    2016 Forde H, Harper E, Davenport C, Rochfort KD, Murphy RP, Smith D, Cummins PM (2016) 'The beneficial pleiotropic effects of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) within the vasculature: A review of the evidence'. Atherosclerosis, 247 :87-96. [Link]
    2016 McGinn C.;MacDonnell B.;Shan C.;Wallace R.;Cummins P.;Murphy R. (2016) 'Microparticles: A pivotal nexus in vascular homeostasis and disease'. Current Clinical Pharmacology, 11 (1):28-42.
    2016 Rochfort KD, Collins L, McLoughlin A, Cummins PM. (2016) 'Tumour necrosis factor-α-mediated disruption of cerebrovascular endothelial barrier integrity in vitro involves the production of proinflammatory interleukin-6'. Journal of Neurochemistry, 136 (3):564-572. [Link] [DOI]
    2015 Rochfort KD, Cummins PM. (2015) 'Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium'. Microvascular Research, 100 :48-53. [Link] [DOI]
    2015 Davenport CA, Mahmoud WA, Forde H, Ashley DT, Agha A, McDermott J, Sreenan S, Thompson CJ, McGrath F, McAdam B, Cummins PM, Smith D (2015) 'The effects of exogenous insulin and liraglutide on markers of vascular calcification in vitro and on coronary artery calcification in patients with type 2 diabetes mellitus'. European Journal of Endocrinology, 173 :53-61. [Link]
    2015 Rochfort KD, Cummins PM (2015) 'The blood-brain barrier endothelium: a target for proinflammatory cytokines'. Biochemical Society Transactions, 43 :702-706. [Link]
    2015 Rochfort KD, Collins LE, McLoughlin A, Cummins PM. (2015) 'Shear-dependent attenuation of cellular ROS levels can suppress proinflammatory cytokine injury to human brain microvascular endothelial barrier properties'. Journal of Cerebral Blood Flow and Metabolism, 35 (10):1648-1656. [Link] [DOI]
    2015 Rochfort KD, Cummins PM. (2015) 'Thrombomodulin regulation in human brain microvascular endothelial cells in vitro: Role of cytokines and shear stress'. Microvascular Research, 97 :1-5. [Link] [DOI]
    2014 Martin FA, McLoughlin A, Rochfort KR, Davenport C, Murphy RP, Cummins PM (2014) 'Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain'. PLoS ONE, 9 . [Link]
    2013 Martin FA, Murphy RP, Cummins PM. (2013) 'Thrombomodulin and the vascular endothelium: Insights into functional, regulatory, and therapeutic aspects'. American Journal of Physiology - Heart and Circulatory Physiology, 304 :H1585-H1587. [Link]
    2012 Cummins PM. (2012) 'Occludin: One protein, many forms'. Molecular and Cellular Biology, 32 :242-250. [Link]
    2009 Fitzpatrick PA, Guinan AF, Walsh TG, Murphy RP, Killeen MT, Tobin NP, Pierotti AR, Cummins PM. (2009) 'Down-regulation of neprilysin expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production'. International Journal of Biochemistry and Cell Biology, 41 :2287-2294. [Link]
    2009 Harrison M, Murphy RP, O'Connor PL, O'Gorman DJ, McCaffrey N, Cummins PM, Moyna NM. (2009) 'Cellular Microparticle response to a high fat meal is not attenuated by prior exercise'. European Journal of Applied Physiology, 106 :555-562. [Link]
    2009 Cummins PM (2009) 'A new addition to the RAS peptide system: proAngiotensin1-12 (PA12)'. Cardiovascular Research, 82 :7-8. [Link]
    2008 Tobin NP, Henehan GT, Murphy RP, Atherton JC, Guinan AF, Kerrigan S, Cox D, Cahill PA, Cummins PM. (2008) 'Helicobacter pylori-induced inhibition of endothelial cell functions: a role for VacA-dependent nitric oxide reduction'. American Journal of Physiology - Heart and Circulatory Physiology, 295 :H1403-H1413. [Link]
    2008 Colgan OC, Collins NT, Ferguson G, Murphy RP, Birney YA, Cahill PA, Cummins PM. (2008) 'Influence of basolateral conditions on the regulation of brain microvascular endothelial tight junction properties and barrier function'. Brain Research Journal, 1193 :84-92. [Link]
    2007 Colgan, O.C.;Ferguson, G.;Collins, N.T.;Murphy, R.P.;Meade, G.;Cahill, P.A.;Cummins, P.M. (2007) 'Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress'. American Journal of Physiology - Heart and Circulatory Physiology, 292 . [Link] [DOI]
    2007 Cummins PM, von Offenberg Sweeney, Killeen MT, Birney YA, Redmond EM, Cahill PA. (2007) 'Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: A force to be reckoned with'. American Journal of Physiology - Heart and Circulatory Physiology, 292 :H28-H42. [Link]
    2007 Morrow, D;Sweeney, C;Birney, YA;Guha, S;Collins, N;Cummins, PM;Murphy, R;Walls, D;Redmond, EM;Cahill, PA (2007) 'Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo'. American Journal of Physiology - Cell Physiology, 292 :488-496. [DOI]
    2006 Collins NT*, Cummins PM*, Colgan OC, Ferguson G, Birney YA, Murphy RP, Meade G, Cahill PA. (2006) 'Cyclic strain-mediated regulation of vascular endothelial occludin and Z0-1: Impact on intercellular tight junction assembly and function. (*Joint First Author)'. Arteriosclerosis, Thrombosis, and Vascular Biology, 26 :62-68. [Link]
    2005 Morrow D, Scheller A, Birney YA, Sweeney C, Guha S, Cummins PM, Murphy RP, Walls D, Redmond EM, Cahill PA. (2005) 'Notch mediated CBF-1/RBP-Jk-dependent regulation of human vascular smooth muscle cell phenotype in vitro'. American Journal of Physiology - Cell Physiology, 289 :C1188-C1196. [Link]
    2005 von Offenberg Sweeney N*, Cummins PM*, Cotter EJ, Fitzpatrick PA, Birney YA, Redmond EM, Cahill PA. (2005) 'Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation. (*Joint First Author)'. Biochemical and Biophysical Research Communications, 329 :573-582. [Link]
    2005 Morrow D, Sweeney C, Birney YA, Cummins PM, Walls D, Redmond EM, Cahill PA. (2005) 'Cyclic strain inhibits notch-mediated vascular smooth muscle cells in vitro.CIRCULATION RESEARCH'. Circulation Research, 96 :567-575. [Link]
    2004 Cummins PM, Cotter EJ, Cahill PA. (2004) 'Hemodynamic regulation of metallopeptidases within the vasculature.PROTEIN & PEPTIDE LETTERS'. Protein and Peptide Letters, 5 :433-442. [Link]
    2004 Coen P, Cummins P, Birney Y, Devery R, Cahill P. (2004) 'Modulation of PGF-1alpha and nitric oxide production in bovine aortic endothelial cells by conjugated linoleic acid'. Endothelium: Journal of Endothelial Cell Research, 11 :211-220. [Link]
    2004 Birney YA, Cappadona C, Sitzmann JV, Redmond EM, Cummins PM, Cahill PA. (2004) 'Pulse pressure-induced transmural fluid flux increases bovine aortic smooth muscle cell apoptosis in a mitogen-activated protein kinase dependent manner'. Journal of Vascular Research, 41 :363-373. [Link]
    2004 Cotter EJ, von Offenberg Sweeney N, Coen PM, Birney YA, Glucksman MJ, Cahill PA, Cummins PM. (2004) 'Regulation of endopeptidase EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling'. Arteriosclerosis, Thrombosis, and Vascular Biology, 24 :457-463. [Link]
    2004 von Offenberg Sweeney N, Cummins PM, Birney YA, Redmond EM, Cahill PA. (2004) 'Cyclic strain-induced changes in endothelial MMP-2 expression: role in vascular smooth muscle cell migration'. Biochemical and Biophysical Research Communications, 320 :325-333. [Link]
    2004 von Offenberg Sweeney N, Cummins PM, Birney YA, Cullen PJ, Redmond EM, Cahill PA. (2004) 'Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity'. Cardiovascular Research, 63 :625-634. [Link]
    2004 Sweeney CH, Morrow D, Coyle S, Hennessy C, Birney YA, Scheller A, Cummins PM, Walls D, Redmond EM, Cahill PA. (2004) 'Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis and migration via a CBF-1/RBP-Jk dependent pathway'. FASEB Journal, 18 :1421-1423. [Link]
    2003 Kim SI, Grum-Tokars V, Swanson TA, Orgel J, Cotter EJ, Cahill PA, Roberts JL, Cummins PM, Glucksman MJ. (2003) 'Novel roles of neuropeptide processing enzymes: EC3.4.24.15 in the neurome'. Journal of Neuroscience Research, 74 :456-467. [Link]
    2000 Tullai JW, Cummins PM, Pabon A, Roberts JL, Lopingco MC, Shrimpton CN, Smith AI, Martignetti JA, Ferro ES, Glucksman MJ. (2000) 'The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation'. Journal of Biological Chemistry, 275 :36514-36522. [Link]
    1999 Cummins PM, Pabon A, Margulies EH, Glucksman MJ. (1999) 'Zinc coordination and substrate catalysis within the neuropeptide processing enzyme endopeptidase EC 3.4.24.15: identification of active site histidine and glutamate residues'. Journal of Biological Chemistry, 274 :16003-16009. [Link]
    1999 Crack PJ, Wu TJ, Cummins PM, Ferro ES, Tullai JW, Glucksman MJ, Roberts JL. (1999) 'The association of the metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane'. Brain Research Journal, 835 :113-124. [Link]
    1998 Cummins PM, O'Connor B. (1998) 'Pyroglutamyl peptidase: An overview of the three known enzymatic forms'. Biochimica et Biophysica Acta - General Subjects, 1429 :1-17. [Link]
    1996 Cummins PM, O'Connor B. (1996) 'Bovine brain pyroglutamyl aminopeptidase (type-I): purification and characterization of a neuropeptide-inactivating peptidase'. International Journal of Biochemistry and Cell Biology, 28 :883-893. [Link]
    1992 Cummins P, Mulcahy P, O'Connor B. (1992) 'Identification of a dipeptidyl aminopeptidase type-II in the cytosolic fraction of bovine brain'. Biochemical Society Transactions, 20 . [Link]

    Other Journal

    Year Publication
    2020 Forde H, Harper E, Rochfort KD, Wallace RG, Davenport C, Smith D, Cummins PM. (2020) 'TRAIL inhibits oxidative stress in human aortic endothelial cells exposed to pro-inflammatory stimuli' Physiology Reports, 8 . [Link]
    2018 Forde H, Davenport C, Harper E, Cummins P, Smith D (2018) 'The role of OPG/RANKL in pathogenesis of diabetic cardiovascular disease' Cardiovascular Endocrinology and Metabolism, 7 :28-33. [Link]

    Conference Contribution

    Year Publication
    2021 Kostyunina D, Dillon E, Rochfort KD, Cummins PM, McLoughlin P (2021) New Trends in Sex and Gender Medicine Sex different responses to hypoxia in male and female human pulmonary microvascular endothelial cells according to proteomics analysis American Physiological Society Virtual .
    2019 Rochfort KD, Carroll LS, Barabas P, Curtis TM, Ambati BK, Barron N, Cummins PM. (2019) 43rd Annual Meeting of the Irish Endocrine Society Hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells is mitigated with COMP-Ang1 treatment. [WINNER: O’Donovan Medal - Best Speaker Category] Galway, Ireland .
    2019 Kostyunina D, Rochfort K, Cummins PM, McLoughlin P. (2019) Meeting of the American Thoracic Society The hypoxic response of shear aligned endothelial cells: approaching in vivo conditions Dallas TX, USA .
    2018 Harper E, Rochfort KD, Smith D, Cummins PM (2018) 42nd Annual Meeting of the Irish Endocrine Society TRAIL protects from RANKL-induced calcification in the aortic endothelium via an anti-oxidant mechanism Cork, Ireland .
    2018 Rochfort KD, Barabas P, Carroll LS, Curtis TM, Ambati BK, Barron N, Cummins PM (2018) 42nd Meeting of the Irish Endocrine Society COMP-Ang1 stabilizes hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells Cork, Ireland .
    2018 Rochfort KD, Barabas P, Carroll LS, Curtis TM, Ambati BK, Barron N, Cummins PM (2018) 50th Meeting of the International Society for Eye Research COMP-Ang1 stabilizes hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells Belfast, Northern Ireland .
    2018 Rochfort KD, Barabas P, Carroll LS, Curtis TM, Ambati BK, Barron N, Cummins PM (2018) New Frontiers in Ocular Therapeutics COMP-Ang1 stabilizes hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells University College Dublin, Ireland .
    2017 Forde H, Davenport C, Durkan E, Thompson CJ, Agha A, O’Gorman DJ, Cummins PM, Smith D. (2017) 41st Annual Meeting of the Irish Endocrine Society Association of serum TRAIL with cardiovascular disease in patients with Type 2 diabetes Dublin, Ireland .
    2017 Harper E, Forde H, Davenport C, Rochfort KD, Smith D, Cummins PM. (2017) 41st Annual Meeting of the Irish Endocrine Society TRAIL protects from RANKL-induced calcification in an in vitro vascular co-culture model, in part via attenuation of NF-κB pro-calcific signalling Dublin, Ireland .
    2017 Piouceau L, Rowan SC, Rochfort KD, Cornwell J, Cummins PM, McLoughlin P. (2017) 38th IUPS Congress Preserving lung function ex vivo prior to transplantation by perfusing with an optimized viscosity solution Rio de Janeiro, Brazil .
    2016 Harper E, Forde H, Davenport C, Rochfort KD, Smith D, Cummins PM. (2016) 40th Annual Meeting of the Irish Endocrine Society Investigating the protective effect of TRAIL on RANKL-induced calcification using a vascular cell co-culture model [WINNER: Montgomery Medal - Best Poster Category] Belfast, Ireland .
    2016 Forde H, Davenport C, Wallace RW, Rochfort KD, Murphy RP, Cummins PM, Smith D. (2016) Beaumont Hospital/RCSI Sheppard Prize Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reduces endothelial oxidative stress in pro-atherogenic conditions [WINNER: Sheppard Prize - Best Poster Category] Dublin, Ireland .
    2016 Forde H, Harper E, Davenport C, Rochfort KD, Cummins PM, Smith D (2016) 40th Annual Meeting of the Irish Endocrine Society Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reduces oxidative stress in human aortic endothelial cells exposed to inflammatory stimuli Belfast, Ireland .
    2015 Forde H, Davenport C, Cummins PM, Smith, D. (2015) 17th European Congress of Endocrinology TRAIL downregulates Endothelin 1 and upregulates Superoxide Dismutase 1 in human aortic endothelial cells under proatherogenic conditions Dublin, Ireland .
    2015 McDonnell C, Bojenov E, McLoughlin A, Cummins PM, Kerrigan SW (2015) International Society on Thrombosis and Hemostasis 2015 Congress Vascular endothelium dysregulation following Staphylococcous aureus infection: New insights for sepsis Toronto, Canada 20/06/2015- 25/06/2015.
    2014 Forde H, Davenport C, McLoughlin A, Hynes L, Smith D, Cummins PM (2014) 39th Annual Meeting of the Irish Endocrine Society TRAIL reduces constitutive and stimulated IL-6 release from human aortic endothelial cells Galway, Ireland 08/11/2014- 09/11/2014.
    2014 McLoughlin A, McDonnell C, Kerrigan SW, Cummins PM (2014) 16th International Symposium on Staphylococci and Staphylococcal Infections Disruption of blood-brain barrier phenotype by Staphylococcus aureus infection: an in vitro HBMvEC model Chicago IL, USA 26/08/2014- 29/08/2014.
    2014 Davenport C, Cummins PM, Smith D. (2014) Beaumont Hospital/RCSI Sheppard Prize Meeting The role of osteoprotegerin and receptor activator of nuclear factor kappa-beta ligand in vascular calcification and the influence of insulin and liraglutide on this process in type 2 diabetes mellitus [WINNER: Sheppard Prize - Best Poster Category] Dublin, Ireland 20/03/2014- .
    2014 Davenport C, Rochfort KD, Martin FA, MacDonnell B, Murphy RP, Smith D, Cummins PM (2014) 38th Annual Meeting of the Irish Endocrine Society Endothelial cells induce osteoblastic activity in smooth muscle cells in a paracrine manner that is enhanced by receptor activator of nuclear factor kappa-beta ligand (RANKL) Kilkenny, Ireland 08/11/2014- 09/11/2014.
    2013 McLoughlin A, McDonnell C, Kerrigan SW, Cummins PM (2013) Staph GBI 2013 Disruption of blood-brain barrier phenotype by Staphylococcus aureus infection: an in vitro HBMvEC model Dublin, Ireland 05/09/2013- 06/09/2013.
    2013 McDonnell C, McLoughlin A, Cummins PM, Kerrigan SW (2013) 24th Congress of the International Society of Thrombosis & Haemostasis Molecular mechanisms of S. aureus mediated endovascular infection under fluid shear conditions Amsterdam, The Netherlands 29/06/2013- 04/07/2013.
    2013 Shan C, McDonnell B, Dowling P, McGinn C, Cummins P, Murphy R (2013) 8th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease 2013 The role of the actin binding protein merlin in the pathogenesis of cardiovascular disease Rotterdam, The Netherlands 18/04/2013- 19/04/2013.
    2013 McDonnell B, McGinn C, Shan C, Cummins PM, Meade G, Murphy R (2013) 8th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease 2013 The impact of cyclic strain on the miRNA profile in vascular smooth muscle cells Rotterdam, The Netherlands 18/04/2013- 19/04/2013.
    2013 McGinn C, Fitzpatrick P, Shan C, Murphy A, McDonnell B, Dowling P, Cummins PM, Murphy R (2013) 8th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease 2013 Palladin, LASP-1 & drebrin, and their presence in endothelial-derived microparticles Rotterdam, The Netherlands 18/04/2013- 19/04/2013.
    2012 Davenport C, Martin FA, Rochfort KD, Murphy RP, Cummins PM, Smith D (2012) 37th Annual Meeting of the Irish Endocrine Society The effects of inflammation, hyperglycemia and cyclic strain on OPG production in human aortic smooth muscle cells [WINNER: O'Donovan Medal - Best Speaker Category] Dublin, Ireland .
    2012 Shan C, McDonnell B, McGinn C, Dowling P, Cummins P, Murphy R (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Molecular and cellular dynamics of merlin in vascular cells via mechanotransduction Chicago, IL, USA .
    2012 McGinn C, Fitzpatrick P, Shan C, Murphy A, McDonnell B, Dowling P, Cummins P, Murphy R (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Investigation of the protein interactions of the shear-responsive protein, palladin, and its presence in endothelial-derived microparticles Chicago, IL, USA .
    2012 McDonnell B, McGinn C, Shan C, Fitzpatrick, Barron N, Cummins P, Murphy A, Degryse B, Meade G, Murphy R (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology The impact of cyclic strain on focal adhesion signaling and miRNA profile in vascular smooth muscle cells Chicago, IL, USA .
    2012 Davenport C, Martin FA, Rochfort KD, Murphy RP, Smith D, Cummins PM (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology The effects of inflammation, hyperglycemia and cyclic strain on OPG production in human aortic smooth muscle cells Chicago IL, USA 17/04/2012- 20/04/2012.
    2012 Martin FA, Rochfort KD, Davenport C, Guinan AF, Murphy RP, Cummins PM (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Cyclic strain-induced release of thrombomodulin from human aortic endothelial cells Chicago IL, USA 17/04/2012- 20/04/2012.
    2012 Rochfort KD, Martin FA, Murphy RP, Cummins PM (2012) 13th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Characterization of inflammatory cytokine effects on the blood-brain barrier using an in vitro human brain microvascular endothelial cell model Chicago IL, USA 17/04/2012- 20/04/2012.
    2011 Shan C, Murphy A, McDonnell B, Dowling P, McGinn C, Cummins PM, Murphy RP (2011) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System The role of merlin in haemodynamic regulation of cytoskeleton organization and cell adhesion in endothelial cells Hyannis MA, USA 16/10/2011- 20/10/2011.
    2011 McGinn C, Fitzpatrick P, Shan C, Murphy A, McDonnell B, Dowling P, Cummins PM, Murphy RP (2011) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System Palladin, a shear-responsive cytoskeletal adaptor protein, is present in endothelial-derived microparticles Hyannis MA, USA 16/10/2011- 20/10/2011.
    2011 McDonnell B, McGinn C, Shan C, Fitzpatrick, Barron N, Cummins PM, Murphy A, Degryse B, Meade G, Murphy RP (2011) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System The impact of cyclic strain on focal adhesion signaling and miRNA expression in vascular smooth muscle cells Hyannis MA, USA 16/10/2011- 20/10/2011.
    2010 Walsh TG, Murphy RP, Fitzpatrick P, Rochfort KD, Guinan AF, Murphy A, Cummins PM (2010) 13th International Symposium of the Blood Brain Barrier Stabilization of brain microvascular endothelial barrier function by shear stress involves a signaling pathway adherens and tight junctions University Hospital Zurich, Switzerland 02/09/2010- 04/09/2010.
    2009 Cummins PM (2009) Physiology 2009: Symposium - Signalling in the Vascular Wall Mechanoregulation of endothelial barrier function University College Dublin, Ireland 08/07/2009- 10/07/2009.
    2009 Walsh TG, Fitzpatrick P, Murphy RP, Cummins PM (2009) 12th International Symposium of the Blood Brain & Blood Retinal Barriers Blood brain barrier regulation by laminar shear stress: role of VE-Cadherin and Rac1 in tight junction assembly and barrier function University College London, UK 09/09/2009- 11/09/2009.
    2009 Murphy A, Britto M, Fitzpatrick P, Barron N, O'Gorman D, Cummins P, Murphy R (2009) XXII Congress of The International Society of Thrombosis & Haemostasis Biomechanical regulation of microRNA expression and endothelial phenotype in vitro Boston MA, USA 11/07/2009- 16/07/2009.
    2008 Walsh TG, Fitzpatrick P, Murphy RP, Cummins PM (2008) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System Regulation of blood brain barrier function by shear stress: role of Rho-GTPases in tight junction assembly and function Hyannis MA, USA 11/09/2008- 14/09/2008.
    2008 Britto M, Fitzpatrick P, Meade G, O'Gorman D, Moyna N, Barron N, Cummins PM, Murphy RP (2008) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System The role of hemodynamic stimuli on endothelial cell microRNA expression signature: potential new regulators of actin binding proteins Hyannis MA, USA 11/09/2008- 14/09/2008.
    2008 Fitzpatrick P, Britto M, Walsh TG, Meade G, Cummins PM, Murphy RP (2008) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System Cytoskeletal re-organistation by mechano-transduced LASP-1 regulates cell-matrix and cell-cell adhesion through activation of Rac1 Hyannis MA, USA 11/09/2008- 14/09/2008.
    2008 Guinan AF, Fitzpatrick PA, Walsh TG, Murphy RP, Cummins PM (2008) North American Vascular Biology Organization (NAVBO) Workshop: Biology of Signaling in the Cardiovascular System Shear Stress Regulates Neprilysin Expression in Vascular Endothelial Cells via an NADPH Oxidase-Dependent Signaling Mechanism Hyannis MA, USA 11/09/2008- 14/09/2008.
    2007 Killeen MT, Murphy RP, Cahill PA, Cummins PM (2007) 8th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Cyclic strain of vascular endothelial cells reduces smooth muscle cell proliferation, possibly via an MMP-2 dependent mechanism Chicago IL, USA 19/04/2007- 21/04/2007.
    2007 Fitzpatrick P, Britto M, Meade G, Cahill PA, Cummins PM, Murphy RP (2007) 21st International Society of Thrombosis and Haemostasis Congress The mechanoregulation of LASP-1 in the pathogenesis of cardiovascular disease Geneva, Switzerland 06/07/2007- 12/07/2007.
    2007 Britto M, Fitzpatrick P, Meade G, Cahill PA, Cummins PM, Murphy RP (2007) 21st International Society of Thrombosis & Hemostasis Molecular and cellular dynamics of moesin in vascular cells via mechano-transduction Geneva, Switzerland 06/07/2007- 12/07/2007.
    2006 Fitzpatrick PA, Killeen MT, Birney YA, Glucksman MJ, Cahill PA, Cummins PM (2006) 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Shear stress regulation of NEP is mediated via reactive oxygen species in endothelial cells Denver CO, USA 27/04/2006- 29/04/2006.
    2006 Tobin N, Cummins PM, Henehan G, Cahill PA (2006) 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Helicobacter pylori outer membrane protein affects vascular endothelial cell fate decisions in vitro Denver CO, USA 27/04/2006- 29/04/2006.
    2006 Colgan OC, Cummins PM, Collins NT, Birney YA, Ferguson G, Cahill PA (2006) 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Co-culture of bovine brain microvascular endothelial cells (BBMvEC) and C6 glioma decreases endothelial permeability and increases tight junction formation Denver CO, USA 27/04/2006- 29/04/2006.
    2006 Colgan OC, Collins NT, Birney YA, Ferguson G, Cahill PA, Cummins PM (2006) 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Shear stress regulates microvascular endothelial occludin and ZO-1 and increases tight junction formation Denver CO, USA 27/04/2006- 29/04/2006.
    2005 Collins NT, Cummins PM, Colgan OC, Birney YA, Ferguson-Welsby G, Murphy RP, Cahill PA (2005) American Heart Association Scientific Sessions Cyclic strain regulates occludin and ZO-1 expression, phosphorylation and localization in bovine aortic endothelial cells (BAECs) Dallas TX, USA 13/11/2005- 16/11/2005.
    2005 Birney YA, Sweeney CH, Morrow D, Guha A, Cummins PM, Walls D, Redmond EM, Cahill PA (2005) American Heart Association Scientific Sessions Vascular smooth muscle cell migration and notch signaling Dallas TX, USA 13/11/2005- 16/11/2005.
    2005 Morrow D, Sweeney C, Birney YA, Cummins PM, Guha S, Murphy R, Walls D, Redmond EM, Cahill PA (2005) American Heart Association Scientific Sessions Sonic hedgehog regulates vascular smooth muscle cell fate in vitro through VEGF activation of notch signaling Dallas TX, USA 13/11/2005- 16/11/2005.
    2005 Morrow D, Guha ST, Birney YA, Sweeney YA, Cummins PM, Walls D, Redmond EM, Cahill PA (2005) 6th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Hedgehog regulation of notch signaling in vascular smooth muscle cells in vitro Washington DC, USA 28/04/2005- 30/04/2005.
    2005 Fitzpatrick PA, Cotter EJ, Birney YA, Glucksman MJ, Cahill PA, Cummins PM (2005) 6th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Expression of thermolysin-like zinc metalloendopeptidases in vascular endothelial cells is regulated by shear stress and reactive oxygen species Washington DC, USA 28/04/2005- 30/04/2005.
    2005 Cotter EJ, Fitzpatrick PA, Birney YA, Wu TJ, Glucksman MJ, Cahill PA, Cummins PM (2005) 6th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Cyclic strain induces changes in EP24.15 subcellular localization and peptide cleavage: possible implications for endothelial cell fate decisions Washington DC, USA 28/04/2005- 29/04/2005.
    2004 Morrow D, Sweeney CH, Birney YA, Cummins PM, Walls D, Redmond EM, Cahill PA (2004) American Heart Association Scientific Sessions The role of notch target genes, HRT-1, HRT-2 and HRT–3 in determining vascular smooth muscle cell proliferation and apoptosis New Orleans LA, USA 07/11/2004- 10/11/2004.
    2004 Collins NT, Colgan OC, Cummins PM, Ferguson-Welsby G, Murphy RP, Cahill PA (2004) American Heart Association Scientific Sessions Cyclic strain regulates occludin and Z0-1 expression, phosphorylation and localisation in bovine aortic endothelial cells (BAEC) New Orleans LA, USA 07/11/2004- 10/11/2004.
    2003 Scheller A, Morrow DJ, Sweeney CH, Walls D, Cummins PM, Redmond EM, Cahill PA (2003) 4th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology Notch signaling and vascular smooth muscle cell differentiation Washington DC, USA 21/04/2003- 24/04/2003.
    2003 Morrow D, Sweeney C, Scheller A, Walls D, Cummins PM, Cahill PA (2003) Experimental Biology - Translating the Genome Notch receptor ligand signaling role in vascular smooth muscle cell proliferation San Diego CA, USA 11/04/2003- 15/04/2003.
    2003 Coen PM, Cummins PM, Devery R, Cahill PA (2003) Experimental Biology - Translating the Genome The effects of conjugated linoleic acid on nitric oxide synthase expression and activity in vascular endothelial cells San Diego CA, USA 11/04/2003- 15/04/2003.
    2003 Cotter EJ, Cahill PA, Cummins PM (2003) Experimental Biology - Translating the Genome Chronic cyclic strain modulates activity of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells San Diego CA, USA 11/04/2003- 15/04/2003.
    2002 von Offenberg Sweeney N, Birney Y, Cummins PM, Cahill PA (2002) Experimental Biology - Translating the Genome Cyclic strain induces pro-MMP2 release from bovine aortic endothelial cells via a Gialpha protein-independent, MAP kinase-dependent pathway New Orleans LA, USA 20/04/2002- 24/04/2002.
    2002 von Offenberg Sweeney N, Cummins PM, Cahill PA (2002) American Heart Association Scientific Sessions Role of SHC/MAP kinase pathway and Gialpha proteins in cyclic strain-induced increases in Pro-MMP2 secretion Chicago IL, USA 17/11/2002- 20/11/2002.
    2001 Cummins PM, Coen PM, Cahill PA (2001) American Heart Association Scientific Sessions Regulation of endopeptidase EC 3.4.24.15 expression in vascular endothelial cells by mechanical forces Anaheim Ca, USA 11/11/2001- 14/11/2001.
    Certain data included herein are derived from the ? Web of Science (2023) of Clarivate. All rights reserved.

    Professional Associations

    Association Function From / To
    Irish Endocrine Society Nominated member 01/11/2014 -

    Employment

    Employer Position From / To
    Dublin City University Associate Professor 01/10/2017 -
    Dublin City University Senior Lecturer 01/10/2015 - 30/09/2017
    Dublin City University Lecturer 01/07/2007 - 30/09/2015
    Dublin City University Senior Scientist 01/06/2000 - 31/08/2007
    Institute of Technology, Tallaght Lecturer in Biology 01/03/1999 - 30/06/2000
    Mount Sinai School of Medicine, New York, USA Postdoctoral Research Fellow 04/03/1996 - 04/03/1999

    Education

    Start date Institution Qualification Subject
    01/10/1987 Dublin City University BSc Biotechnology
    01/10/1991 Dublin City University PhD Biochemistry

    Research Interests

    Vascular cell physiology, signaling, and endothelial dysfunction

    The blood-brain and blood-retinal barriers

    Models of astrocyte/endothelial interaction in the brain

    Current Postgraduate Students

    Student Name Degree Supervision
    Aleksejenko ,Natalija PhD-track Supervisor

    Modules Coordinated

    Term Title Subject
    2020 Scientific Literature BE257
    2022 Advanced Bioanalysis Laboratory BE454
    2022 Practical Biochemistry Laboratory BE261
    2022 Animal Cell Biotechnology BE435
    2022 Professional Skills for Scientists BE537
    2022 Description of 2021_BE494 BE494
    2022 Biomolecules and Metabolism BE201
    2022 Research Project BE492
    2022 Literature Review & Experimental Design BE487
    2022 Literature Review & Experimental Design BE489
    2022 Physiological Systems & Cell Biology BE226
    2022 Research Project BE488
    2022 Analytical Science Literature Survey BE493